Thursday Night Football Odds: 49ers Huge Favorites (-10) & More TNF Betting Odds

Fact Checked by Blake Weishaar
Thursday Night Football Odds

Key Takeaways

  • πŸ”₯ The 49ers are 10-point favorites against the Giants in Week 3 on Thursday Night Football.
  • ❌ Giants RB Saquon Barkley has been ruled out with an ankle injury.
  • πŸ“Ί The Week 3 Thursday Night Football matchup between SF & NYG kicks off at 8:15 p.m. ET on Prime Video on Sept. 21.

Thursday Night Football is here and so is Kentucky sports betting! TNF brings a juicy Week 3 matchup for gamblers in Kentucky and NFL fans everywhere.

Thursday Night Football Odds Week 3: Giants @ 49ers

🏈 Point SpreadNYG +10 (-108), SF -10 (-112)
πŸ’° MoneylineNYG +425, SF -575
πŸ“Š Total44.5 (O -108/U -112)
βœ… Last Updated:September 22, 2023

The 49ers went from 7.5-point favorites to 10-point favorites against the Giants, who started out the season with a 40-0 blowout loss to the Cowboys before a historic comeback win vs. the Cardinals in Week 3. The 49ers have easily covered the spread in three of the last four times they were favored against the Giants.

The over/under total was also lowered over the last week from 49.5 to 44.5. However, in four of their last five matchups dating back to 2014, these two teams have gone over the projected total.

🎁 MORE: Best Promo Codes & Bonus Codes in Kentucky

TNF Betting Odds: 2023 Schedule Breakdown

It's another very exciting slate of Thursday Night Football matchups. Below we compare the best vs. the worst TNF games to bet on:

Best TNF Matchups Based On Betting Odds

πŸ“… Week 11CIN @ BAL
πŸ“… Week 12SF @ SEA
βœ… Last Updated:September 22, 2023

Bengals @ Ravens

These two teams have won the AFC North in four of the last five seasons, so this game will likely be important for both division and playoff standings. Could it have a real impact on the No. 1 seed in the AFC as well? We'll know by this point in the season how the new-look Lamar Jackson-led Ravens offense looks with new offensive coordinator Todd Monken.

49ers @ Seahawks

Geno Smith's Seattle Seahawks were one of the NFL's surprise teams last season and lost to the 49ers in the playoffs. With the Rams starting a youth movement and the Cardinals rebuilding, these are likely to be the NFC West's top two teams. Will Brock Purdy recreate last year's magic?

Note: This game is being played on Thanksgiving, technically not under the traditional Thursday Night Football branding.

Worst TNF Matchups Based On Betting Odds

πŸ“… Week 8Bucs at Bills
πŸ“… Week 9Titans at Steelers
πŸ“… Week 16Saints at Rams
βœ… Last Updated:September 22, 2023

Bucs @ Bills

The Bills should be a Super Bowl contender. The Bucs should be a disaster. The only double-digit spread of the TNF season makes this a little interesting, but Buffalo will probably be able to name its score. Kyle Trask may be starting by this point in the season for Tampa Bay.

πŸ”₯ MORE: Latest Super Bowl Odds

Titans @ Steelers

No offense to the Titans and Steelers, they just don't tend to play very exciting games. A lot of running, a lot of inconsistent quarterback play from Kenny Pickett and Ryan Tannehill or Will Levis is likely. And it will probably come down to a late field goal.

Saints @ Rams

A rematch of the extremely controversial 2019 NFC Championship Game, this one will likely be far less interesting. The Rams are rebuilding and it's highly unlikely they'll be in playoff contention at this point, while the Saints will probably be on their way to the playoffs (they're favored in 14 games this season) due to an easy schedule and weak NFC South.

 
BetMGM.com for Ts & Cs. Must be 21+ to wager. KY only. New Customer Offer (If applicable). All promotions are subject to qualification and eligibility requirements. Rewards issued as non-withdrawable bonus bets. Bonus bets expire in 7 days from issuance. Gambling Problem? Call 1-800-GAMBLER.

2023 Thursday Night Football Schedule

 Mobile Kentucky sports betting apps are launching the same day as Week 4's TNF matchup. Check out the latest odds for every game below. 

πŸ“… Week 1 (Kickoff)❌ FINAL: DET 21, KC (-4) 20
πŸ“… Week 2❌ FINAL: MIN 28, PHI (-6.5) 34
πŸ“… Week 3NYG @ SF (-10)
πŸ“… Week 4DET @ GB (-1.5)
πŸ“… Week 5CHI @ WAS
πŸ“… Week 6DEN @ KC
πŸ“… Week 7JAX @ NO
πŸ“… Week 8TB @ BUF
πŸ“… Week 9TEN @ PIT
πŸ“… Week 10CAR @ CHI
πŸ“… Week 11CIN @ BAL
πŸ“… Week 12 (Black Friday)MIA @ NYJ
πŸ“… Week 13*SEA @ DAL
πŸ“… Week 14*NE @ PIT
πŸ“… Week 15*LAC @ LV
πŸ“… Week 16*NO @ LAR
πŸ“… Week 17*NYJ @ CLE
βœ… Last Updated:September 22, 2023

*Weeks marked with an asterisk are subject to flex scheduling.

In Week 10, No. 1 pick Bryce Young gets to duel with Justin Fields and the Bears, who traded away the top pick and chance to draft Young.

How To Bet On Thursday Night Football Odds

There are a variety of ways to bet on Thursday Night Football, from spread to moneyline to total. There are also player props and live wagers, which allow bettors the ability to bet anytime during a game.

πŸ”₯ MORE: Bet TNF Odds with BetMGM Sportsbook in Kentucky

 
BetMGM.com for Ts & Cs. Must be 21+ to wager. KY only. New Customer Offer (If applicable). All promotions are subject to qualification and eligibility requirements. Rewards issued as non-withdrawable bonus bets. Bonus bets expire in 7 days from issuance. Gambling Problem? Call 1-800-GAMBLER.

Thursday Night Football Live Betting

Live betting is an exciting way to bet TNF because there is always an option for another bet. Bettors also can use information learned from watching the game to make a more informed wager, or react to an injury that takes place.

πŸ”₯ MORE: Live Bet TNF with FanDuel Sportsbook in Kentucky

 
Must be 21+ and present in KY. Bonus issued in non-withdrawable bonus bets that expires 30 days after FanDuel accepts its first real money sports wager in KY (β€œGo Live Date”). Unique user identity verification required. Offer ends on the Go Live Date. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER

Bet the TNF Moneyline

Betting on the TNF moneyline means that bettors are wagering simply on which team will win the game. Given the wide range of outcomes for teams on Thursday Night Football with travel, previous opponents, etc., betting on the moneyline can be a good way to make a simple bet.

πŸ”₯ MORE: Bet TNF Moneyline with Caesars Sportsbook in Kentucky

Bet the TNF Spread

Betting on the spread on Thursday Night Football is the most popular way that bettors like to wager on the game. Given the wider variety of outcomes of TNF games (versus Sunday or Monday night games), the spread is another good way to bet on the game. The highest-scoring TNF game ever was the Rams beating the 49ers 41-39 in Week 3 of the 2017 season.

πŸ”₯ MORE: Bet TNF Spread with DraftKings Sportsbook in Kentucky

TNF Props

There are a wide variety of available Thursday Night Football prop bets, ranging from alternate spreads to player props. Since Thursday night games are separated from the rest of the week, operators offer more markets because there will more betting action on the game. There have been more player props put forth in recent seasons.

πŸ”₯ MORE: Bet TNF Props with ESPN BET Sportsbook in Kentucky (formerly Barstool Sportsbook)

 
BetMGM.com for Ts & Cs. Must be 21+ to wager. KY only. New Customer Offer (If applicable). All promotions are subject to qualification and eligibility requirements. Rewards issued as non-withdrawable bonus bets. Bonus bets expire in 7 days from issuance. Gambling Problem? Call 1-800-GAMBLER.

TNF Parlays

There are many ways to build parlays around TNF. Parlay wagers are a series of bets which all must win in order for the bet to cash. They can offer a higher payout if the game goes according to the script a bettor believes. 

In other words, if in a Lions-Chiefs game, a bettor thinks it's going to be a high-scoring game and Patrick Mahomes will throw for a bunch of yards, he/she can parlay the game total OVER, Chiefs to cover and Mahomes to go OVER his passing yardage prop.

πŸ”₯ MORE: Bet TNF Parlays with bet365 Sportsbook in Kentucky

 
This offer is available to customers residing in Kentucky that sign up from 6:00am ET on August 28, 2023. Must be aged 18+ and fully verified for identity by bet365. To qualify for this offer, sign up during the qualifying sign-up period and receive $10 in Bonus Bets for each touchdown scored in the Lions vs. Packers game, taking place on Thursday, September 28, 2023. The maximum amount of Bonus Bets that can be claimed for this offer is $50. To claim your Bonus Bets, go to the Account menu, choose My Offers and click Claim.

Historical TNF Betting Trends

Just like teams have less time to prep before taking the field on Thursday nights, Kentucky bettors will also have less time to research and place bets. Here are some important factors to remember when betting on Thursday Night Football odds.

TNF Betting Tips

Before placing bets on Thursday Night Football, be sure to do your research. Unders went 11-6 in TNF in 2023, while road teams went 10-7. Be sure to pay attention to injury reports, as players have far less time to recover from the previous weekend's games

No. 1: Do your research

Thursday Night Football is a different handicap than the rest of the week's games. Bettors need to research when/where teams previously played, if they're coming off a bye, potential injuries and more.

No. 2: Monitor the injury report

With only four days before a game instead of seven, there is much less time for players to recover. Players injured the previous Sunday and questionable, or worse, heading into Thursday are a lot less likely to play in a TNF game.

No. 3: When in doubt, lean under

With the reduced rest, players still recovering from last Sunday's games and decreased time to prepare and execute game plans, TNF games can be tough to watchβ€”and low-scoring. Unders were 11-6 last season, including games of 19-3, 12-7 and 12-9.

TNF Most Memorable Games in NFL History

Playing in primetime always raises the stakes in the NFL. Let's take a look back at some of the best Thursday night matchups we've seen in recent memory.

Week 13, 2015: Packers 27, Lions 23

Richard Rodgers Catching

Lions fans, avert your eyes. Green Bay trailed 17-0 in the first quarter and was down 20-0 before Aaron Rodgers led a furious comeback. Rodgers' famous 61-yard looping Hail Mary TD to Richard Rodgers as time expired capped off the all-time classic.

Week 3, 2017: Rams 41, 49ers 39

Todd Gurley Touchdown

Jared Goff threw for 292 yards and three TDs, while workhorse running back Todd Gurley II carried the load with 113 yards rushing and two TDs. Both teams had over 420 yards of total offense, as the 49ers came back from down 15 in the fourth quarter, but missed a two-point conversion with just over two minutes left in the game that would've tied it. 

This was the highest-scoring game in TNF history.

Week 15, 2018: Chargers 29, Chiefs 28

Mike Williams Two Point Conversion

Down 28-14 in the fourth quarter, it seemed like Patrick Mahomes & Co. were on their way to another win. Instead, Philip Rivers led the Chargers on two TD drives in the fourth-quarter, including one with 4 seconds remaining. Instead of kicking the extra point, the Chargers went for two ... and converted, leading to a 29-28 win. Both teams came into the game 11-3, so it was a big-time matchup.

How To Watch Thursday Night Football in 2023

Thursday Night Football will be available on Prime Video primarily at 8:15 p.m. ET every week, along with NBC for some games. Games are also available with an NFL+ subscription.

Al Michaels and Kirk Herbstreit will announce TNF for the second straight year.

Final Word on 2023 TNF Odds

Thursday Night Football is the first opportunity each week to bet on the NFL! With expanded legalization of sports betting in the U.S., sportsbooks are offering more spread, moneyline, total and player props on TNF than ever before, which means more opportunities for bettors to win. Be sure to do your research before wagering, and have fun!

 
Must be 21+ and present in KY. Bonus issued in non-withdrawable bonus bets that expires 30 days after FanDuel accepts its first real money sports wager in KY (β€œGo Live Date”). Unique user identity verification required. Offer ends on the Go Live Date. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER

Thursday Night Football Odds FAQs

Author

Shannon Lane is a commercial editor for Gambling.com Group overseeing BetKentucky.com. She's spent the last decade working in sports media, including at NFL Media in digital content programming and strategy, and as a reporter and fact-checker at Sports Illustrated. She graduated from Northwestern University with a concentration in journalism where she covered football, lacrosse, basketball and volleyball.

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